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63,156 This observation holds significance in the context of diseases that frequently manifest in the forebrain, such as glioblastoma, suggesting the potential effectiveness of intranasal administration for therapeutic intervention

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It should also be noted that, from a methodological perspective, the model used (Cox with stratification by cardiovascular risk class of the trials, i.e., SURPASS-4: high risk, and all others: low risk) requires various assumptions, including the homogeneity of the relative effect of tirzepatide treatment on MACE regardless of the baseline cardiovascular risk level of the patients