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Nearly all functional homologues of yeast autophagy-related genes have been found in higher eukaryotes and humans, further confirming their primary role in the degradation pathways for organelles and proteins (Sheng and Qin, 2019)

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As sensation seeking has long been implicated in the reinforcing effects of psychostimulants 52 , we thus proposed a reinforcement loop underlying the maintenance of smoking, where smoking behaviour could reduce GMV in the right vmPFC, leading to disinhibited reward-seeking behaviour (i.e., higher sensation seeking), and hence, in turn, promote future smoking behaviour

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