Combined NNMT inhibitor treatment with reduced-calorie diet achieved 6.3 g cumulative weight loss versus 2.9 g with diet alone, and fat mass reduction was ten-fold greater with treatment (~29.3%) compared to diet switch alone (2.9%), while restoring fatty liver profiles to lean-control levels (Sampson et al., 2021)
May improve insulin sensitivity
This triple-agonist approach works by[4,5]: Slowing stomach emptying after meals, helping you feel fuller longer Stabilizing blood sugar levels by stimulating insulin release Influencing glucagon signaling, which may increase energy expenditure Because many GLP-1 medications produce weight loss as a side effect, clinicians often prescribe them for weight management even in people without type 2 diabetes
That distinction is the point
They are the ones who find the dose that produces consistent, tolerable, sustainable progress and stay there