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Symptoms are similar to those of acne

Recent multi-omics analyses by Cappellani et al., for instance, have provided strong genetic and proteomic evidence linking DR pathogenesis directly to the activation of specific immune pathways, including the complement system and adaptive T-cell responses [53, 58, 59]

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But roughly 10% to 15% of patients in those trials were nonresponders who lost less than 5% of their body weight