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Interestingly, like BETP, compound 2 interacts with cysteine 347 6.36 via covalent modification at the cytoplasmic side of GLP-1R, consistent with our previous observation that an intact extracellular domain (ECD) is required for the activity of BETP and compound 2 34 albeit the basis for such a requirement remains unknown

And they say the global market is going to reach $71 billion by 2032 with Novo and Eli Lilly each accounting for 45% of its sales

acylation to extend half-life, modifications to improve receptor selectivity or bias, PEGylation) are used to improve pharmacokinetics, dosing interval, and tolerability