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Poor sleep accelerates amyloid-beta accumulation in the brain, and pineal dysfunction is common in Alzheimer disease
It is used when physicians insert medication, usually corticosteroids and local anesthetics, into the epidural space that surrounds the nerve roots in the cervical or thoracic spine
doi: 10.1038/s41588-021-00880-5 69 BottiniNMusumeciLAlonsoARahmouniSNikaKRostamkhaniMet al
The efficacy of the new pharmacotherapies will allow clinicians to treat obesity towards individualised treatment targets, similar to what is happening with other chronic diseases such as T2D or dyslipidaemia
Systemic adverse effects appear to be uncommon based on available reports, but comprehensive adverse event profiles are lacking due to the paucity of large-scale clinical investigations
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