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What is measured in these rats and mice (and occasionally in small groups of human volunteers) is often not a hard endpoint like muscle strength or weight loss, but surrogate biomarkers: molecules in the blood that have an indirect link to a hard endpoint

The 3-AR is expressed predominantly in adipose tissue and plays an important role in regulating lipolysis the breakdown of stored triglycerides into free fatty acids and glycerol

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IGF-1 LR3, a more stable form of insulin-like growth factor, provides extended support for muscle cell growth and repair