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7 Compared with placebo, patients taking metformin had an increased risk of vitamin B 12 deficiency (number needed to harm = 14 per 4.3 years) and low vitamin B 12 levels (number needed to harm = 9 per 4.3 years)

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NNMT is an enzyme that regulates energy metabolism by methylating nicotinamide, a precursor to NAD+, into 1-methylnicotinamide

Archived from the original (PDF) on 27 September 2017