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1930s 1950s Medical professionals noticed an increase in lung cancer

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Since smoking may result in altered response or adverse reactions to drugs and other therapeutic treatments, appropriate dose adjustments and patient surveillance should be taken into consideration by clinicians

[12] More specifically, peptic ulcers erode the muscularis mucosae, at minimum reaching to the level of the submucosa (contrast with erosions, which do not involve the muscularis mucosae)

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