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For M2 polarization, RAW264.7 cells were stimulated with IL-4 (20 ng mL 1 , ABclonal, China) for 24 h

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PT-141 (bremelanotide) is a synthetic melanocortin receptor agonist peptide derived from melanocortin analog research

There is only one clinical trial for lixisenatide in PD, assessing its efficacy in slowing motor disability progression in early-stage patients over 12 months, followed by a 2-month washout period