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Treated groups showed changes in several muscle-function measurements

24,29 Through this receptor, GLP-1 leads to an increase of cAMP levels that thereafter activates protein kinase A (PKA)

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The reasons for these changes, apart from excess ROS leading to increased GSH depletion in cardiomyocytes, are disturbances in the anabolic process of GSH, causing a further decrease in intracellular GSH content

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