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To infiltrate the islet, T cells must trigger the cathepsin-mediated loss of peri-islet ECM to bypass the peri-islet membrane ( Figure 2 )

It contains a bacteriostatic agent, so it is not for use in newborns and should be used with caution in pregnancy or where large cumulative volumes could be given, following the relevant warnings

This suggests that components involved in TJ disassembly may represent useful therapeutic targets by limiting the impact of enteric pathogens on intestinal barrier integrity and restricting their systemic spread