Shared decisionmaking is essential in scenarios such as borderline BMI thresholds, older age with frailty, complex polypharmacy, or psychiatric comorbidity, where benefitrisk calculus is individualized
It's a general increase in food awareness
Future research should characterize GIPR with single-cell ocular transcriptomics, directly compare Tirzepatide with pure GLP-1 RAs for IOP and retinal outcomes across metabolic contexts, and incorporate ophthalmic endpoints in cardiometabolic trials to better define the risk-benefit profile
The agency will continue to work with manufacturers to help resolve the current shortages, and, as shortages resolve, will closely monitor the situation and provide any assistance we can to help manufacturers ensure an adequate supply
Adequate B-12 levels may help improve mood and reduce symptoms of depression