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Ryan [26] noted numerous etiological factors contributing to lung cancer disparities, including smoking (i.e., screening age, dose, duration, cessation, menthol, genetics, and metabolism), environment (i.e., body mass index, alcohol consumption, radon, pollution, and geographic location), early detection (i.e., screening eligibility, screening uptake, and biomarkers), societal factors (stage at presentation, insurance status, belief systems, socioeconomic status, access to care, use of care, and health literacy), and biology (i.e., genetics and metabolism, transcriptomics, and biomarkers)

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After maturity and other processing steps, the cured leaf is utilized for smoking, chewing, snuffing, and nicotine extraction