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A single e-liquid cartridge contains the same amount of nicotine as a pack of cigarettes and lasts 2 weeks on average

The life cycle is not completed at temperatures below 17C

Abbreviations CI: Chief investigator CO: Carbon monoxide COPD: Chronic obstructive pulmonary disease CRF: Case report form DMP: Data management plan eCRF: Electronic case report form FTCD: Fagerstrom test for cigarette dependence GCP: Good clinical practice GDPR: General Data Protection Regulation GP: General practitioner HRA: Health Research Authority LC-MS/MS: Liquid chromatography-tandem mass spectrometry NCSCT: National centre for smoking cessation training Ng/ml: Nanograms per millilitre NHS: National health service NICE: National Institute for Health and Care Excellence NIHR: National Institute for Health Research NRT: Nicotine replacement therapy PC-CTU: Primary care clinical trials unit PHE: Public Health England PIS: Patient information sheet ppm: Parts per million QOF: Quality and outcomes framework RCT: Randomised controlled trial REC: Research ethics committee SAE: Serious adverse event SMI: Serious mental illnesses SSS: Stop smoking services SOP: Standard operating procedure TSC: Trial Steering Committee References Office for National Statistics: Adult smoking habits in the UK: 2018

When Stanwyck and Holden were presenting the Best Sound Oscar for 1977, Holden paused to pay a special tribute to her for saving his career when Holden was cast in the lead for Golden Boy (1939)