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Description

PDE4 inhibitors, including CC-11050, CC-3052, and roflumilast, when combined with INH, have been shown to reduce the lung bacillary burden, lung pathology, and fibrosis, as well as the size and number of lung granulomas in M.tb -infected rabbits and in both acute and chronic TB mouse models [35, 108, 109]

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La Vignera S, Condorelli RA, Cannarella R, Duca Y, Calogero AE

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This "bubble" protects the nutrient as it travels through the harsh environment of the stomach

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doi: 10.1016/0165-1781(95)02656-h 191

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The biotech is also eyeing a regulatory submission to the European Medicines Agency next year

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