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The functional prediction performed using phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt) and Kyoto encyclopedia of genes and genomes (KEGG) implicated that the depleted gut microbiome was associated with metabolic pathways, including those related to carbohydrates, butanoate, and amino acids (Supplementary Fig

Dipeptidyl-peptidase IV (CD26) role in the inactivation of regulatory peptides

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The application is based on a 64-week trial of 307 adults with obesity but without diabetes

Gene analysis Reverse transcription and total RNA extraction of the target genes Total RNA was obtained from ovary samples using the Trizol reagent in accordance with the manufacturers instructions (Direct-zol TM RNA MiniPrep, cat No