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[47] The most well-known hereditary influence related to nicotine dependence is a mutation at rs16969968 in the nicotinic acetylcholine receptor CHRNA5 , resulting in an amino acid alteration from aspartic acid to asparagine

As a child she wanted to be a Hollywood star like Shirley Temple, as did many other young girls of her time

I knew Spaniards on this island of Espaola who were accustomed to take it, and being reprimanded for it, by telling them it was a vice, they replied they were unable to cease using it

(en) Teo et al