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22, 1975, with the publication of the editorial entitled Cigarette smoking, coronary heart disease and sudden death ( Can Med Assoc J 113: 919, 1975), this Journal has recorded the proven and potential hazards of smoking-related to pulmonary carcinoma, chronic bronchitis, and emphysema to the smoker

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[49] Reinforcement disorders Tolerance An appreciable tolerance to cocaine's high may develop, with many addicts reporting that they seek but fail to achieve as much pleasure as they did from their first experience

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