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It has been reported that p53 mutant lung cancer patients exhibited increased expression of immune checkpoint regulators, enhanced CD8 T cell infiltration and increased expression of effector T cell and interferon- associated genes [194]

It is common in children but can occur at any age

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Moderate confidence Assessments are based on credibly sourced and plausible information, but are not of sufficient quality or are not sufficiently corroborated to warrant a higher level of confidence