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As mentioned above, GSH cellular concentrations are regulated by GSH-mediated GCL inhibition (Figures 2, 3)
Nobody could have predicted that a couple scientists looking for hormones in angler fish or a guy squirting lizard venom on a rodent pancreas would lead to this
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In agreement with the noncompetitive behavior of 9 and as determined by structural superposition of the cryo-EM structure and the X-ray NADPH-TGR- complex 17 , inhibitor 9 does not sterically interfere with NADPH binding
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