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The reason is the content of nicotine

From: 13, Patterns of Tobacco Use Among U.S

Similar to the results of carbonylation, total ubiquitinated and p62 protein levels increased in cells exposed to 10% CSE and increased further with 20% CSE exposure (Figure 4E-G)

By two or three I learned not to kneel, not to expect, to plant my fires underground where none but the dolls, perfect and awful, could be whispered to or laid down to die