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Collagen is the skins scaffolding and without it the skin loses its elasticity and starts to wrinkle and sag

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Participants in this group with e-cigarette use within 5 or more years of quitting tobacco were 1.65 (95% CI, 1.05-2.58) times more likely to develop lung cancer and 4.46 (95% CI, 1.85-10.75) times more likely to experience a lung cancer-specific death than those in the group without e-cigarette use within 5 or more years