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Neurobiol Dis 33:133142 Jayakumar AR, Panickar KS, Murthy C, Norenberg MD (2006) Oxidative stress and mitogen-activated protein kinase phosphorylation mediate ammonia induced cell swelling and glutamate uptake inhibition in cultured astrocytes

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This elicits copious production of ROS superoxide anion and peroxide by the inflammatory cells (102, 149)