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(Juul has frequently denied accusations that its products or marketing have ever been aimed at minors, and the companys CEO, Kevin Burns, has recently warned nonsmokers not to take up vaping.) When vapes flooded the American consumer market in the early 2010s, concerns over the products unknown long-term health impacts were tempered by modest optimism about their ability to steer smokers away from the catastrophic dangers of cigarettes

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The Wnt signaling pathway effector TCF7L2 is upregulated by insulin and represses hepatic gluconeogenesis