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However, the route, speed and amount of nicotine absorption (and subsequent nicotine levels in plasma) are important determinants of the efficacy of ECs to serve as smoking substitutes and of any concerns about nicotine overdose or intoxication

Contrary to popular belief, shisha smoking is dangerous, the water in the shisha pipe does NOT absorb harmful substances in the smoke

Nicotine belongs to a family of compounds called alkaloids and occurs naturally in several varieties of plant, including tomatoes, aubergines and potatoes, but is found at its highest levels in the tobacco plant

Benzene : Long-term exposure to benzene can damage the bone marrow, leading to a low red blood cell count or anemia

have legalized adult use for those aged 21 and up and as of October 2025, 40 states and D.C