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Aschner, M
From a mechanistic perspective, L-carnitine stimulates fatty acid beta-oxidation , reducing their buildup in sebaceous glands, while EGCG exerts potent anti-inflammatory and antioxidant effects, limiting sebaceous hyperactivity and protecting cells from oxidative stress
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A balanced, whole-food diet incorporating these elements is recommended for overall metabolic health rather than targeting isolated nutrients, in line with NICE and NHS dietary guidance
Moreover, there are several paradigmatic conditions such as Down syndrome, phenylketonuria, and various lipidoses (Scriver et al., 1989) where the metabolic abnormalities are expressed in both neural and peripheral tissues, but the functional consequences are most profound in the central nervous system (CNS)
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