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36 The present study reveals that CSE-induced PlGF expression is mainly mediated by the MAPK (ERK-1/2) pathway based on our following findings: first, CSE rapidly induced ERK-1/2 phosphorylation and increased its nuclear ingression (Figure 4A and B) and second, ERK-1/2 inhibitor U0126 inhibited CSE-induced Egr-1 and PlGF upregulation (Figure 4C)

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I felt kind of nauseous