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Lancet 366 , 9991004 (2005)

10.4014/jmb.1703.03039 57 QuareshyM.ShanmugamM.TownsendE.JamesonE.BuggT

The resultant lactylated/acetylated HMGB1, released via macrophage-derived exosomes, subsequently enhances endothelial cell permeability

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Most chemicals, either produced by the body or to which we are exposed through our diet and environment, first undergo phase I detoxification, which produces highly reactive and carcinogenic by-products