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A significant limitation of the study was the relatively small number of people who were using e-cigarettes at the beginning of the trial, making it difficult to be confident that the results would be replicated in a larger e-cigarette user sample

The advanced formulation using reconstituted material was assessed for the presence of key chemical constituents found in tobacco products including nitrosamines, tar, and ammonia

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Smoking and All-Cause Mortality in Older People

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