Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type 2 diabetes
In contrast, later in 2023, a multisociety statement from gastroenterology and hepatology organizations, including the AGA, AASLD, ACG, ASGE, and NASPGHAN, advised against routine discontinuation of GLP-1 therapy, emphasizing individualized patient management and the use of point-of-care gastric ultrasound (POCUS) to assess aspiration risk [9]
Additionally, hexarelin protects cardiomyocytes from angiotensin II-induced apoptosis by reducing caspase-3 activity, increasing Bcl-2 expression, and inhibiting Bax expression (8)
For 503B (outsourcing) facilities, the rule is stricter: they cannot compound a copy at all unless the drug is on the FDA shortage list or they document a clinical difference for an individual patient (which is logistically difficult for bulk manufacturers)
Semaglutide showed benefit in heart failure with preserved ejection fraction in the STEP-HFpEF trial
