However, high doses can lead to GI issues and an increased risk of bleeding due to their blood-thinning properties[273]
Similarly, heavy metals such as cadmium, lead, and mercury, often encountered in industrial settings or contaminated water and food supplies, interfere with mitochondrial function and catalyze the production of free radicals [7, 8]
The causes of hyperhomocysteinemia may be nutritional deficiencies such as a lack of folate, vitamin B6, or vitamin B12, or they may be hereditary, such as congenital hyperhomocysteinemia caused by a methionine synthase deficiency (Al Mutairi 2020)
Amiodarone for the treatment and prevention of ventricular fibrillation and ventricular tachycardia
found that 37.5% of participants completed 12 injections compared to 18.7% in the placebo group, suggesting modest efficacy