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When to consider dose reduction Your dosage may require adjustment over time

Clinical studies, including the STEP (Semaglutide GLP-1 Treatment Effect in People with Obesity) trials, have shown that participants experienced an average weight loss of about 15% over 68 weeks

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Step 3: Lifestyle & Nutrition Coaching Medication is a tool

Last reviewed: June 27, 2026 Last updated: June 27, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations