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Dynamic data was first fit into kinetic models with T 1 as an unknown parameter to estimate apparent in vivo T 1 of VitC, which was subsequently incorporated into the kinetic model as a fixed parameter to generate k assuming T 1 is the same across the subjects

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Toll-like receptor-9 (TLR9), which is a target produced from plasmacytoid dendritic cell (pDC) precursors, has lately acquired popularity in melanoma clinical trials

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