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Pharmacological IRE1 inhibition de-sensitizes cells to ferroptosis As the RNase activity of IRE1 can be inhibited pharmacologically 24 , we tested the effect of specific IRE1 RNase inhibitors including 48c 19 and MKC9989 25 , on erastin-induced ferroptosis

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[1] The technical term for this category of medicine is subcutaneous medication , meaning it is administered under (sub-) the skin (cutaneous)

FIGURE 5 6.2 Pyroptosis and DOR There is a strong relationship between pyroptosis and inflammation