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Sci Rep 8:1145 Gonzalez Suarez I, Martin F, Marescotti D, Guedj E, Acali S, Johne S, Dulize R, Baumer K, Peric D, Goedertier D, Frentzel S, Ivanov N, Mathis C, Hoeng J, Peitsch MC (2016) In vitro systems toxicology assessment of a candidate modified risk tobacco product shows reduced toxicity compared to a conventional cigarette

Dimensions41.7, 62mm

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Thus, chronic exposure to cigarette smoke causes persistent inflammation and oxidative stress in the lungs, leading to repeated repair and remodeling (leading to airway remodeling), stimulating mucus hypersecretion (leading to chronic bronchitis), and degrading the alveolar walls (leading to emphysema) (Fig