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Figure 2 shows that deiodinase type 1 (DIO1) transforms the inactive thyroid hormone thyroxine (T4) into the active form of thyroid hormone triiodothyronine (T3) [32]

Although in vivo treatment suggested that NMN could have an impact on tumour growth, in vitro experiments with a matrix of chemotherapy and cancer cell lines showed no impact of NMN on cell survivalsuggesting that any impact may be due to altered growth kinetics, rather than interfering with the efficacy of chemotherapy

Id probably bring Marty [Makary] on as well from the FDA

D'Souza RW, Francis WR, Andersen ME: Physiological model for tissue glutathione depletion and increased resynthesis after ethylene dichloride exposure

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