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Critically, this technique 'offered a powerful tool for studying the triggering events at the initiation of the immune system' (Andersson, Sjberg, Obel)

146,147,148 Recent developments feature Sudoscan as a reliable early detection method and advanced skin biopsy techniques to assess IENFD

Topical evidence is stronger and includes IRB-approved human trials

Notably, PCC samples exhibited downregulation of the antioxidant protein peroxiredoxin 6 (PRDX6) and upregulation of oxidative stress-associated proteins particularly vanin-1 (VNN1) and paraoxonase-3 (PON3)

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