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The central nicotinic cholinergic receptors, namely the low affinity 7 and the high affinity 42 nicotinic receptors located in the ventral tegmental area (VTA), are stimulated by nicotine resulting in a rapid release of dopamine in the nucleus accumbens, mediating the rewarding and reinforcing effects of nicotine (25) (Figure 1)
The warnings in English and French include "poison in every puff, tobacco smoke harms children and cigarettes cause impotence. Health Canada said the strategy aims to reduce tobacco use below 5% by 2035
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