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Adequate time should be allowed without straining, and the urge to defecate should never be ignored or delayed when possible

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(111) reported that a dose of 50 mg/kg SIN significantly restored levels of ROS, MDA, HO-1, and SOD in a temporal lobe epilepsy rat model, partially inhibiting the increase in NF-B, TLR4, TNF- , GFAP, and Caspase-1, although the effect on glutathione levels was not significant

Nature Reviews Cancer , 12(3), 159-169