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Graphical Abstract Highlights To determine whether there is a potential relationship between glucagon-like peptide 1 receptor agonists (GLP-1RAs) and suicidal or self-injurious behaviors (SSIBs)

Most patients begin noticing appetite suppression within the first two weeks, with visible weight loss typically occurring within 4-6 weeks of consistent use

Measuring insulin became much easier after 1959 when a new technique called radioimmunoassay was published by Rosalyn Yalow, a biophysicist, and Solomon Berson, a physician, based at the Veterans Administration Hospital in New York

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