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Consistent with these findings, adoptive transfer studies have demonstrated that cigarette smoke exposure selectively enhances the proinflammatory properties of Th17 cells and the immunosuppressive activity of Treg cells through a GPR15-dependent mechanism, underscoring GPR15 as a central regulator of divergent T-cellmediated immune responses to environmental factors in colitis

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Unpublished analyses of the 19922000 Census of Fatal Occupational Injuries Special Research Files provided to NIOSH by the Bureau of Labor Statistics (includes more detailed data than the research file, but excludes data from New York City)