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Cigarette smoke induces pathological changes such as disrupted epithelial layers, ciliary dysfunction, and mucus hypersecretion of the respiratory tract in humans

Ye JB, Zhang Z, Yan J, Hao H, Liu XZ, Yang ZC, Ma K, Yang XP, Mao DP, Zhou H (2017) Degradation of phytosterols in tobacco waste extract by a novel Paenibacillus sp

Taken together, these arguments suggest that alcohol might be an important environmental factor that might affect the penetrance of LHON

Several factors contribute to the link between nicotine and alcohol, including: Shared Addiction Pathways Both nicotine and alcohol act on the brains reward system, particularly the dopamine pathway, which is involved in feelings of pleasure and reward