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In 2001, the Institute of Medicine issued a report faintly welcoming the creation of a safer cigarette as a feasible component of a harm-reduction strategy

[DOI] [PubMed] [Google Scholar] Rezk-Hanna M

The indigenous microorganisms in the processing environment adapt to the local temperature, humidity and tobacco substrate characteristics, and can quickly colonize and multiply on the tobacco leaves, thus affecting the composition and structure of the microbial community in the subsequent fermentation process

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