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Sample Size and Power Calculations As no data are available in the literature on the efficacy of varenicline for gradual cessation in patients with COPD who are poorly motivated to quit, our sample size calculation was based on the cessation rates observed for abrupt cessation in patients with COPD motivated to quit smoking receiving a combination of varenicline and smoking cessation counseling

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For the first few years each inspector received 60 annually, and if the fees collected were insufficient to pay their salary, the deficient amount was made up out of public funds

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