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Oxidative Stress and Nerve Damage: Role in Chemotherapy Induced Peripheral Neuropathy

For both, the cause is connected to alterations of the functionality of the relative enzymes, such as succinate dehydrogenase (SDH) and fumarate hydratase (FH), respectively, that include loss-of-function mutations, transcript degradation by miRNAs, post-translational modifications, and protein degradation

However, the potential therapeutic value of GH replacement therapy needs further investigation as a recent clinical trial found no improvement in ALS patients receiving GH compared to placebo (Sacca 2012)

Targeting of Nrf2 improves antitumoral responses by human NK cells, TIL and CAR T cells during oxidative stress

Muscle Pain and Aches Another side effect seen in some users is muscle pain , also known as myalgia