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Bladder pain syndrome/interstitial cystitis ESSIC type 3C: high expression of inducible nitric oxide synthase in inflammatory cells

Bulsara, K

Discussion Keys findings In our study, using a fully resuscitated large animal model, we demonstrated that inhibition of DPP3 with PCZ was associated with 1/ Decreased catecholamine and fluid requirements with comparable organ perfusion, as assessed by an isotopic method, 2/ Lower vascular and myocardial inflammation, 3/ Lower myocardial injury and 4/ Better pulmonary function, as reflected by higher PaO 2 /FiO 2 ratio

(2024) 187:404360.e30

Chait, and Steven Carr in 1991 who also mentioned that this technique can efficiently detect conformational changes of proteins in solutions (Katta et al., 1991)