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If you experience intolerable side effects when jumping from 5mg to 7.5mg, you can try 6mg or 6.5mg instead

However, the FDA has interpreted this study and put a warning on febuxostat that it should be used second line, after allopurinol

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Furthermore, in ME/CFS, PEM has been associated with defects in the TCA cycle, where a metabolic impairment reduces ATP production and increases lactate accumulation (Nilsson et al., 2020)

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