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A 2024 simulated pharmacokinetic analysis of inhaled caffeine and melatonin in Food and Chemical Toxicology (ScienceDirect S0278691524001674) found these products suffer from a "lack of dosimetric considerations" and that the toxicological concerns "could outweigh the potential beneficial effects." Add the carrier: PG and VG are recognized as safe to eat, but that designation doesn't cover inhaling them, and a review in Inhalation Toxicology linked chronic aerosolized PG to respiratory irritation (PMID: 29020462)

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