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Kooy A et al (2009): Long-term effects of metformin on metabolism and microvascular and macrovascular disease in patients with type 2 diabetes mellitus

In conclusion, the poor performance of Lurcher mice in tests of spatial learning and orientation cannot be attributed only to impairment of these specific functions, but there can be a substantial contribution of other pathological phenotypic traits, more or less directly related to cerebellar dysfunction

Finally, the timeline conversation is where most secretagogue interest collides with biology

Chain breaking by scavenging intermediate radicals such as peroxyl and alkoxyl radicals (vitamins E, C, GSH, uric acid, ubiquinol, bilirubin, etc .) Repair and removal of damaged molecules (methionine sulfoxide reductase, DNA-repair enzymes, chaperons, etc .)

However, it is important to note that the vast majority of this data comes from animal models, and human clinical trial data remains limited